Table 2.
Comparison of demographic data between female patients with elevated or normal PRL levels
| Factors | Elevated PRL RIS/OLZ (n=82/n=47) |
Normal PRL RIS/OLZ (n=40/n=62) |
Statistics RIS/OLZ |
P value RIS/OLZ |
| Age, years | 46.50 (30, 58)/34 (27, 46) | 46(31, 53)/39 (26.75, 51.75) | U=−0.68/0.62 | 0.499/0.536 |
| Illness duration, years | 12.50 (5, 25)/5 (0.92, 12.55) | 12.50 (6.00, 25.75)/6 (1.24, 18.15) | U=−0.20/1.17 | 0.840/0.243 |
| Age of onset, years | 25.5 (20, 31.75)/25 (20, 34) | 25 (21,33)/25 (19.75, 34) | U=0.43/−0.75 | 0.666/0.451 |
| Medication time, years | 0.39 (0.08, 1.56)/0.07 (0, 0.71) | 0.08 (0, 1.81)/0.38 (0.01, 1.36) | U=−2.57/1.83 | 0.010*/0.068 |
| Body mass index, kg/m2 | 23.44 (21.26, 25.29)/23.49 (20.20, 26.23) | 25.18 (22.08, 27.38)/22.11 (20.56, 24.30) | U=1.86/−0.73 | 0.060/0.466 |
| Dose, mg/day | 4 (3, 6)/10 (10, 20) | 3 (2, 4)/10 (5, 15) | U=−3.37/−2.51 | 0.001**/0.012* |
| Fasting plasma glucose, mmol/L | 5.26 (4.90, 5.49)/4.94 (4.44, 5.40) | 5.18 (4.65, 5.77)/5.21 (4.99, 5.59) | U=−0.22/2.03 | 0.827/0.042* |
| Total cholesterol, mmol/L | 4.63 (0.86)/4.71 (0.93) | 4.50 (0.93)/4.59 (0.85) | t=0.76/0.61 | 0.451/0.55 |
| Triglycerides, mmol/L | 1.00 (0.70, 1.28)/1.16 (0.72, 1.78) | 1.25 (0.83, 1.70)/1.40 (0.97, 1.81) | U=1.81/0.82 | 0.070/0.410 |
| PRL, ng/mL | 78.31 (51.32, 136.29)/63.96 (40.09, 111.75) | 7.07 (3.69, 20.70)/12.43 (5.42, 17.76) | —— | —— |
Normal distribution (mean+SD).
Non-normal distribution (median (Q1, Q3)).
*p≤0.05
**p≤0.001
OLZ, olanzapine; PRL, prolactin; RIS, risperidone.