Table 2.

Study schedule and assessments

Outcome measures	Baseline assessment (consent to the study)	Baseline MRI scan	Treatment Monday–Friday for 4–6 weeks	8 weeks follow-up assessment	16 weeks follow-up assessment	16 weeks MRI scan	26 weeks follow-up assessment
Visit window		Within 14 days of Baseline Assessment	+14 days of MRI Scan	±1 week from Randomisation	±1 week from Randomisation	Within 14 days of 16 week Follow-up Assessment	±1 week from randomisation
HDRS-17	✓		✓Only if baseline assessment exceeds 4 weeks	✓	✓		✓
MGH	✓		✓ Only if Baseline assessment exceeds 4 weeks
BDI-II	✓			✓	✓		✓
PHQ-9	✓			✓	✓		✓
WSAS	✓			✓	✓		✓
GAD7	✓			✓	✓		✓
EQ-5D-5L	✓			✓	✓		✓
THINC-it	✓			✓	✓		✓
SCID-5	✓
CTQ	✓
QIDS-SR	✓			✓	✓		✓
Client Resource Questionnaire	✓				✓		✓
Patient Acceptability			✓	✓	✓		✓
Side effects checklist (adverse events)			✓	✓
fMRI		✓				✓
MRI		✓				✓
rsfMRI		✓				✓
MRS		✓				✓
Diffusion-weighted imaging		✓				✓

BDI-II, Beck Depression Inventory-II; CTQ, Childhood Trauma Questionnaire; EQ-5D-5L, EuroQoL-five-Dimensions-5-Level; GAD-7, Generalised Anxiety Disorder-7; HDRS-17, Hamilton Depression Rating Scale-17; MGH, Massachusetts General Hospital; MRS, MR spectroscopy; QIDS-SR, Quick Inventory of Depressive Symptomatology; rsfMRI, resting state functional MRI; SCID-5, Structured Clinical Interview-5; THINC-it, THINC-Integrated Tool; WSAS, Work and Social Adjustment Scale.