Table 3.

Study efficacy outcome measures

Outcomes	Measure	Time points
Primary Outcome	17-Item Hamilton Depression Rating Scale (HDRS-17)	Response at 16 weeks (defined as by a 50% or greater reduction in HDRS-17 score from baseline)
Secondary Outcomes	HDRS-17	Mean change in HDRS-17 score compared with baseline at 8, 16 and 26 weeks Response (as defined above) at 8 weeks and at 26 weeks Sustained response at 16 and 26 weeks (defined as a continuing response as defined above following a response at the previous time point) Remitters at 8, 16 and 26 weeks (defined as a score of 7 or less on the HDRS-17)
	Beck Depression Inventory-II	At 8, 16 and 26 weeks
	Patient Health Questionnaire Quick Inventory of Depressive Symptomatology	At 8, 16 and 26 weeks At 8, 16 and 26 weeks
	Generalised Anxiety Disorder Assessment	At 8, 16 and 26 weeks
	THINC Integrated Tool	At 8, 16 and 26 weeks
	EuroQol-five-Dimensions-five-Level	At 8, 16 and 26 weeks
	Work and Social Adjustment Scale	At 8, 16 and 26 weeks
	Patient Acceptability (1–5 scale)	After each TMS session and at 8, 16 and 26 weeks
	Adverse Events Checklist	After each TMS session and 8 weeks
	MRI scan (structural (T1), diffusion-weighted imaging (DWI) for structural connectivity, resting state fMRI for functional connectivity (FC) and effective FC (eFC), and GABA MRS of the DLPFC and insula	T1, DWI, FC, eFC at baseline (all centres) GABA at baseline and T1, DWI, FC, eFC, GABA at 16 weeks (all sites except London).

DLPFC, dorsolateral prefrontal cortex; fMRI, functional MRI; MRS, MR spectroscopy; TMS, transcranial magnetic stimulation.