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. 2020 Jul 6;8(2):e000550. doi: 10.1136/jitc-2020-000550

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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Prognostic value of TMBRB in immunotherapy. (A) and (B) The Kaplan-Meier curves depicting OS in high- and low-risk groups of OS and the high- and low-risk groups of PFS. (C) The receiver operating curves for TMB to distinguish between high- and low-risk groups and its best cut-off points (OS: 0.61; PFS: 0.46), which reflects the most likely cut-off points of TMB to be used for risk stratification (OS: 9.35; PFS: 9.27). (D) The distribution of TMBRB in immunotherapy data set, and the best cut-off points of TMBRB for OS and PFS. AUC, area under the curve; OS, overall survival; PFS, progression-free survival; TMBRB, tumor mutational burden radiomic biomarker.