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. 2019 Aug 16;28(20):3443–3465. doi: 10.1093/hmg/ddz176

Figure 2.

Figure 2

CD mice have deficits in USVs and decreased social investigation. (A) Call rate across 2 days shows that on Postnatal Day 5 CD animals produce fewer USVs than either WT or Gtf2i* littermates. (B) Schematic of the three-chamber social approach task. (C) All genotypes show preference for social stimulus in three-chamber social approach assay. (D) Gtf2i* and CD animals show similar dominance behavior to WT animals in the tube test for social dominance. (E) Schematic of the resident intruder paradigm. (F) CD animals show decreased time engaged in anogential sniffing in resident intruder task. (G) CD animals show decreased time engaged in nose-to-nose sniffing in resident intruder task. *P < 0.05, **P < 0.01, ***P < 0.001 Sample sizes are shown as numbers in parentheses.