Figure 5.

CD mice have altered mRNA for synaptic genes in a hippocampus transcriptome. (A) CD animals show decreased expression of the WSCR that are expressed in the hippocampus. (B) Volcano plot comparing CD and WT differentially expressed genes. WSCR genes are highlighted in yellow and genes with FDR < 0.1 are highlighted in red. (C) Besides Gtf2i and Gtf2ird1 there are no significantly differentially expressed genes (D) There is a 9% overlap between nominally significantly up and down regulated genes between CD and Gtf2i^* comparisons to WT controls. (E) CD differentially expressed genes are enriched for GO biological processes involved in synapses and nervous system development. (F) Gtf2i^* differentially expressed genes are enriched for GO biological processed involved in more general organ development.