Fig 6. Phylogenetic tree for AA9 LPMOs for which xyloglucan activity has been unequivocally demonstrated.

Red labels indicate LPMOs with a substitution-intolerant cleavage pattern, whereas blue labels indicate a less restricted cleavage pattern; black labels indicate that the cleavage pattern is unknown. Regioselectivity on cellulose (C1, C4, or C1/C4) and activity on soluble cello-oligosaccharides (full circle, active; cross, inactive; no sign, unknown) are indicated after the enzyme name. For more information on phylogeny, including less well characterized AA9 LPMOs, see S2 Fig in S1 Appendix.