TABLE 5.
Mixed-effects models reported as unit change or fold changea
| Figure | y-axis term | x axis | Change | Group | Estimate of change (95% CI) | P value (within-group change)b | P value (between groups) |
|---|---|---|---|---|---|---|---|
| 6B | CD107a+ | Time (wpi) | Unit change per additional wpi | B57 negative | 0.100 (0.055 to 0.145) | <0.0001 | 0.27 |
| B57 positive | 0 .0635576 (0.016 to 0.111) | 0.008 | |||||
| 6C | GrzA+ | Time (wpi) | Unit change per additional wpi | B57 negative | −0.058 (−0.102 to −0.014) | 0.010 | 0.52 |
| B57 positive | −0.037 (−0.084 to +0.010) | 0.12 | |||||
| 6Fc | CD107a− GrzA+ GrzB− IFN-γ− IL-2− Perforin+ TNF+ | Time (wpi) | Percent change per additional wpi | B57 negative | −1.6% (−2.2% to −1.1%) | <0.0001 | 0.002 |
| B57 positive | −0.3% (−0.9% to +0.3%) | 0.27 | |||||
| 6G | CD107a− GrzA− GrzB− IFN-γ+ IL-2− Perforin− TNF− | Time (wpi) | Percent change per additional wpi | B57 negative | −0.9% (−1.2% to −0.5%) | <0.0001 | 0.043 |
| B57 positive | −0.3% (−0.7% to +0.1%) | 0.13 | |||||
| 7E | PD1+ TIGIT+ | Time (wpi) | Unit change per additional wpi | B57 negative | 0.040 (−0.015 to +0.095) | 0.15 | 0.091 |
| B57 positive | 0.108 (0.052 to 0.165) | <0.001 | |||||
| 7F | PD1+ TIGIT+ | Viral load [log10(copies/ml)] | Unit change for each 10-fold difference in viral load | B57 negative | 5.805 (−2.105 to +13.715) | 0.15 | 0.031 |
| B57 positive | 19.504 (9.946 to 29.061) | <0.001 | |||||
| 7G | PD1+ TIGIT+ | CD4 count [log2(cells/μl)] | Unit change per 2-fold increase in CD4 count | B57 negative | −6.634 (−16.999 to +3.731) | 0.21 | 0.17 |
| B57 positive | −17.109 (−28.032 to −6.186) | 0.002 | |||||
| 7H | PD1+ TIGIT+ | CD4% | Unit change per CD4 percentage point increase | B57 negative | −0.739 (−1.463 to −0.015) | 0.046 | 0.25 |
| B57 positive | −1.338 (−2.058 to −0.619) | <0.001 | |||||
| 7I | PD1+ TIGIT+ | CD4/CD8 ratio | Unit change per unit increase in CD4/CD8 ratio | B57 negative | −22.956 (−43.032 to −2.881) | 0.025 | 0.41 |
| B57 positive | −34.071 (−50.909 to −17.233) | <0.001 | |||||
| 8B | 2B4+ | Time (wpi) | Unit change per additional wpi | B57 negative | 0.118 (0.077 to 0.159) | <0.0001 | 0.83 |
| B57 positive | 0.124 (0.084 to 0.165) | <0.0001 | |||||
| 8B | CD160+ | Time (wpi) | Unit change per additional wpi | B57 negative | 0.018 (−0.015 to +0.052) | 0.28 | 0.002 |
| B57 positive | 0.093 (0.060 to 0.125) | <0.0001 | |||||
| 8B | KLRG1+ | Time (wpi) | Unit change per additional wpi | B57 negative | 0.102 (0.060 to 0.144) | <0.0001 | 0.33 |
| B57 positive | 0.132 (0.090 to 0.173) | <0.0001 | |||||
| 8B | PD1+ | Time (wpi) | Unit change per additional wpi | B57 negative | 0.040 (−0.013 to +0.093) | 0.14 | 0.099 |
| B57 positive | 0.102 (0.050 to 0.154) | 0.0001 | |||||
| 8B | TIGIT+ | Time (wpi) | Unit change per additional wpi | B57 negative | 0.041 (−0.005 to +0.087) | 0.079 | 0.035 |
| B57 positive | 0.110 (0.065 to 0.155) | <0.0001 | |||||
| 9B | T-bethi Eomesdim | Time (wpi) | Percent change per additional wpi | B57 negative | −0.1% (−0.3% to +0.1%) | 0.18 | 0.097 |
| B57 positive | −0.4% (−0.6% to −0.2%) | <0.001 | |||||
| 9C | T-betdim Eomeshi | Time (wpi) | Percent change per additional wpi | B57 negative | +0.1% (−0.1% to +0.2%) | 0.43 | 0.16 |
| B57 positive | +0.2% (+0.1% to +0.4%) | 0.007 | |||||
| 9D | T-bet− Eomes− | Time (wpi) | Percent change per additional wpi | B57 negative | 0.0% (−0.2% to +0.3%) | 0.84 | 0.002 |
| B57 positive | −0.5% (−0.8% to −0.3%) | <0.001 |
a
The null hypothesis corresponds to 0 (unit change) or 0% (percent change). B57, HLA-B*57; CI, confidence interval. Boldface indicates statistical significance (P < 0.05).
b
H0, the null hypothesis; no change.
c
A zero-inflated negative binomial (ZINB) regression was used to account for the high number of absent cell populations (0 values).