TABLE 2.
Dose-inhibition curve characteristics of gO genotype mutant strainsa
| gO GT mutant | sPDGFRα-Fc dose-response curve in: |
sNRP2-Fc dose-response curve in ARPE-19 cells |
||||
|---|---|---|---|---|---|---|
| HFFs |
ARPE-19 cells |
|||||
| Mean IC50 (range [ng/ml]) | Slope | Mean IC50 (range [ng/ml]) | Slope | Mean IC50 (range [ng/ml]) | Slope | |
| GT1c | 58 (52–63) | 6.0–8.0 | 39 (16–53) | 2.6–6.0 | 59 (40–79) | 1.4–1.6 |
| GT2b | 73 (54–92) | 6.0–8.0 | 36 (10–51) | 2.6–3.0 | 64 (39–89) | 1.4–1.7 |
| GT3 | 65 (53–82) | 4.8–10.0 | 47 (43–50) | 4.7–6.0 | 42 (28–56) | 1.5–1.6 |
| GT3/1c | 49 (46–54) | 6.0–9.5 | 50 (49–50) | 6.8–7.4 | 65 (41–100) | 0.9–1.8 |
| GT1c/3 | 69 (56–81) | 2.5–6.2 | 30 (13–62) | 1.0–2.6 | 88 (73–98) | 1.2–2.4 |
| GT4 | 52 (47–55) | 5.5–6.0 | 55 (52–56) | 5.3–6.0 | 54 (48–61) | 1.2 |
| GT5 | 68 (45–100) | 5.3–8.0 | 56 (54–58) | 5.3–6.0 | 63 (34–92) | 1.3–1.9 |
a
The data shown are the results of two to four independent experiments. Inhibitor concentration (IC50) and slope values were calculated from inhibitor concentration-versus-response four-parameter dose-response curves.