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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Neurobiol Dis. 2020 May 15;141:104947. doi: 10.1016/j.nbd.2020.104947

Figure 1: Dosing timeline, weaning strategy, cage and group assignments.

Figure 1:

A) Time line of develop mental dieldrin exposure model: In this paradigm, only female dams were fed dieldrin. Exposure began at 8 weeks of age with 0.3 mg/kg dieldrin dissolved in a corn oil vehicle and administered vi a peanut butter pellet. Males were introduced for mating when females were 12 weeks of age. Pregnancy was confirmed by monitoring weight. Dieldrin administration continued until pups (F1) were weaned at PND22. B) Weaning strategy, cage and group assignments for PFF injections: At weaning, pups (F1) were separated by sex and litter (colors represent different litters) with no more than 4 animals per cage (grey boxes represent cages). No animals that were singly housed were used in this study. Within each cage, animals were assigned to groups such that for every experimental group, all animals were from independent litters. Created in BioRender.