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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Neurobiol Dis. 2020 May 15;141:104947. doi: 10.1016/j.nbd.2020.104947

Figure 10: Proposed mechanism by which developmental dieldrin exposure leads to exacerbation of PFF-induced toxicity.

Figure 10:

Dams are fed vehicle or dieldrin containing food starting 1 month prior to mating and continuing through weaning of F1 pups. Dieldrin inhibits chloride influx through GABAA receptors resulting in increased neuronal activity (A). This change in activity produces epigenetic changes throughout the lifespan even when dieldrin is no longer present (B). These epigenetic changes affect dopamine neuron development and maintenance, producing stable changes in striatal dopamine synapse function (C). These synaptic changes lead to increased susceptibility to PFF-induced synucleinopathy (D, E). Created in BioRender.