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. 2020 Jul 8;40(28):5495–5509. doi: 10.1523/JNEUROSCI.2235-19.2020

Figure 1.

Figure 1.

Rapid increase in inhibition after eye opening in nf1+/− mice. A, Schematic illustration of the experimental approach. Electrophysiological recordings are performed in layer 2/3 of V1 in mice before and after eye opening at P10-P11 and P12-P13. B, Representative traces of sIPSCs in WT and nf1+/− mice before and after eye opening at P10-P11 and P12-P13. C, Average amplitude and frequency of sIPSCs. The frequency of sIPSCs increases significantly faster in nf1+/− mice, compared with WT mice: two-way ANOVA, F(1,63) = 6.72, p = 0.01, post hoc Tukey's, WT: P10-P11 (n = 23 cells from 9 mice) versus P12-P13 (n = 10 cells from 4 mice), p = 0.55, nf1+/−: P10-P11 (n = 17 cells from 5 mice) versus P12-P13 (n = 17 cells from 5 mice), p < 0.0001, P12-P13: WT versus nf1+/−, p = 0.03, whereas the amplitude remains unchanged (two-way ANOVA, F(1,63) = 0.028, p = 0.87). D, Cumulative distributions of sIPSC amplitudes and interevent intervals in P10-P11 and P12-P13 mice. *p < 0.05, ****p < 0.0001.