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. 2020 Jul 8;40(28):5347–5361. doi: 10.1523/JNEUROSCI.0250-20.2020

Figure 2.

Figure 2.

Exacerbated Aβ pathology in LRP4 deficiency 5xFAD mice. A, Reduced LRP4 protein in 5xFAD;GFAP-Lrp4f/f mice compared with 5xFAD;Lrp4f/f. B, Quantitative data in A. n = 3 for each group. t(4) = 11.2, p = 0.0004, unpaired t test. C, D, Increased Aβ deposition in 6-mo 5xFAD;GFAP-Lrp4f/f mice cortex and hippocampus, compared with 5xFAD;Lrp4f/f. Scale bar, 500 µm. Representative images (C) and quantification of area covered by Aβ plaque (D). n = 4 for each group. Ctx: t(6) = 4.061, p = 0.0066; Hippo: t(6) = 3.121, p = 0.0205, unpaired t test mo, month old. E, Increased TBS-soluble Aβ1-42 in 6-mo 5xFAD;GFAP-Lrp4f/f mice brain, compared with 5xFAD;Lrp4f/f. n = 4 for each group. Aβ1-40: t(6) = 1.231, p = 0.2642; Aβ1-42: t(6) = 2.822, p = 0.0303, unpaired t test. F, Increased GDN-soluble Aβ1-40 and Aβ1-42 levels in 6-mo 5xFAD;GFAP-Lrp4f/f mice brain, compared with 5xFAD;Lrp4f/f. n = 4 for each group. Aβ1-40: t(6) = 3.455, p = 0.0135; Aβ1-42: t(6) = 2.557, p = 0.0431, unpaired t test. Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.