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. 2020 Jul 8;40(28):5347–5361. doi: 10.1523/JNEUROSCI.0250-20.2020

Figure 5.

Figure 5.

A further disconnect of the vHPC-PFC by Lrp4 mutation in 5xFAD mice. A, Schematic diagram of in vivo recording. Two tetrodes were implanted in vHPC and PFC, respectively. LFPs were recorded in free-moving 6-mo mice in an open field. B, Coherence between vHPC and PFC LFPs of Lrp4f/f (n = 10), GFAP-Lrp4f/f (n = 9), 5xFAD;Lrp4f/f (n = 14), and 5xFDA;GFAP-Lrp4f/f (n = 11) mice. C, vHPC-PFC synchrony at different frequencies: Delta, F(3,40) = 8.389, p = 0.0002, ANOVA; Theta, F(3,40) = 14.84, p < 0.0001, ANOVA; Beta, F(3,40) = 35.28, p < 0.0001, ANOVA; Gamma, F(3,40) = 15.76, p < 0.0001, ANOVA. Data are mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.