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Incidence rate of drug-related AE outcomes resulting from regorafenib treatment and placebo.
| Drug-related AE outcomes | Number of events/sample size |
Incidence rate % (95% CI) |
||
|---|---|---|---|---|
| Regorafenib | Placebo | Regorafenib | Placebo | |
| Permanent discontinuation | 132/1362 | 25/737 | 9.7% (8.1–11.2) | 3.3% (2.1–4.6) |
| Transient interruptions | 430/751 | 71/425 | 57.2% (53.7–60.8) | 16.7% (13.1-20.2) |
| Dose reductions | 593/1262 | 53/685 | 47% (44.2–49.7) | 7.7% (5.7–9.7) |
AE, adverse event.
