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. 2020 Jun 23;12(12):11185–11199. doi: 10.18632/aging.103534

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Copyright © 2020 Yen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Midlife humanin treatment improves metabolic health in mice. Twice weekly treatment with HNG in midlife improves weight (A) without changing food intake (B). There were also improvements in body composition with a decreased values in visceral fat (C), an increase in lean body mass (D), and no change in subcutaneous fat (E). Although there was no significant difference in lifespan with this low of a dose of humanin (F), there was a significant decrease in circulating IGF-I (G) and a trend (p<.1) for leptin (H). *indicates p<.05 +indicates p<.10.