Table 1. Demographic characteristics and neuropsychological test of all sample participants.

	APOEε4 carriers (n=129)	APOEε4 noncarriers (n=717)	Main APOEε4 effect	Main age effect	Age×APOE ε4 interaction
Male/Female	47/82	264/453	1a
Age (years)	64.90±7.39	65.18±7.34	0.69
Education (years)	11.08±3.61	10.82±3.67	0.47
MCI (Y/N)	23/106	97/620	0.22 a
Hypertension (%)	51 (39.5%)	296 (41%)	0.83 a
Hyperlipidemia (%)	69(53.4%)	327 (45.6%)	0.205 a
Diabetes (%)	12 (9.3%)	116 (16.2%)	0.107 a
Coronary heart disease (%)	7 (5.4%)	82 (11.4%)	0.112 a
Cerebrovascular disease (%)	15 (11.6%)	86 (12%)	1 a
Family history of dementia (%)	3 (2.3%)	10 (13.9%)	0.332 a
MMSE	27.29±2.25	27.66±1.96	0.001	<0.0001	0.011
Memory	-0.069±0.75	0.012±0.74	0.063	<0.0001	0.144
Visuo-spatial ability	-0.053±0.91	0.003±0.84	0.383	0.003	0.006
Attention	-0.054±0.74	0.001±0.79	0.051	<0.0001	0.300
Language	-0.009±0.89	-0.001±0.82	0.143	<0.0001	0.028
Executive function	-0.046±0.85	-0.003±0.83	0.292	<0.0001	0.184

Values are mean±standard deviation or Nos. of participants.

aThe p-value for sex and MCI status were obtained using χ2 test.