Figure 7.

miR-145 ameliorated HF-induced defective in Ca²⁺ homeostasis. (A) representative imagines of resting fluorescence at baseline (The arrow marks cardiomyocyte stained with Rhod-2AM); (B) statistical analysis of F₀ (n≥9); (C) representative imagines of cardiomyocytes sarcomere shortening from isolated HF hearts; (D) representative recording (F/F₀) of steady-state Ca²⁺ transients followed by Ca²⁺ waves (The arrow marks Ca²⁺ wave); (E–H) statistical analysis of Ca²⁺ transients in systole and diastole (Baseline and in presence of ISO, n≥9); (I–J) statistical analysis of cell shortening (Baseline and in presence of ISO, n≥9). Data are presented as mean ± SD.