Table 3. ICa characteristics (n≥7).
Sham | HF | AD-EGFP | AD-miR-145 | M+C | |
ICa-peak decay time constant, ms | |||||
τ1 | 6.54±1.16 | 10.57±0.95* | 10.46±1.13* | 9.59±0.83* | 10.46±0.89* |
τ2 | 44.66±6.29 | 65.67±6.73* | 65.96±9.44* | 59.52±3.28* | 62.01±8.51* |
ICa activation kinetics | |||||
V1/2, mV | -9.35 ±1.93 | -4.18±2.26* | -4.84±2.65* | -6.67±1.54* | -7.17±2.78* |
K | 3.65±0.38 | 4.65±0.36* | 4.79±0.38* | 4.18±0.24* | 4.09±0.32* |
ICa inactivation kinetics | |||||
V1/2, mV | -19.56±1.35 | -18.07±1.30 | -17.57±2.48 | -17.32±1.25 | -17.88±2.03 |
K | -1.45±2.01 | 0.16±3.06 | -0.94±2.67 | 3.61±1.59 | -0.84±2.39 |
ICa recovery time constant | |||||
τ, ms | 101.55 | 144.36 | 154.39 | 111.31 | 120.86 |
±9.08 | ±7.88* | ±13.30* | ±11.56#& | ±3.37*# |
V1/2: half-maximal activation or inactivation; K: slope factor; τ: time constant; *P<0.05, compared with sham group; #P<0.05, compared with HF group; &P<0.05, compared with AD-EGFP group. Data are presented as mean ± SEM.