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. 2020 Jun 22;12(12):12002–12018. doi: 10.18632/aging.103366

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Copyright © 2020 Wei et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Inhibition of YAP can reverse the effect of plasma ED-EVs on DSF proliferation. (A, B) YAP expression in different transfected DSF was detected by RT-qPCR and western blot analysis. (C) CCK-8 detected DSF viability after different S-NC treatment. (D, E) Transwell assay measured DSF migration after different treatment. (F) Representative images of EdU results in different transfected DSF. Compared with the blank group, *p < 0.05, **p < 0.01, ***p < 0.001; compared to the ED-EVs group, ###p < 0.001; compared to the NC group, &&& p < 0.001. Data in panels (A, B and D) were analyzed by one-way ANOVA, and data in panel C were analyzed by two-way ANOVA, followed by Tukey's multiple comparisons test. Repetitions = 3.