Table 2. ADME (Adsorption, Distribution, Metabolism, Excretion) properties of compounds.

Number	Compounds	Solubility level	BBB level	CYP2D6c	Hepatotoxicityd	Absorption levele	PPB levelf
1	ZINC000056897657	1	4	0	0	3	0
2	ZINC000035024527	1	4	0	0	3	0
3	ZINC000118912913	0	4	0	0	3	1
4	ZINC000038559596	3	4	0	0	2	0
5	ZINC000013540213	3	3	0	0	0	1
6	ZINC000034944431	2	4	1	0	2	0
7	ZINC000012495022	3	1	0	0	0	1
8	ZINC000002526389	2	4	1	1	0	1
9	ZINC000100013581	3	2	0	0	0	1
10	ZINC000085886023	1	4	1	1	3	1
11	ZINC000013540662	4	4	0	0	1	0
12	ZINC000002528510	2	4	1	1	0	1
13	ZINC000049878068	1	4	0	0	3	0
14	ZINC000003791817	4	3	0	0	0	1
15	ZINC000100822245	2	4	1	0	3	0
16	ZINC000017611788	2	4	0	1	3	0
17	ZINC000012496925	4	3	0	0	0	1
18	ZINC000008219593	3	1	0	0	0	1
19	ZINC000032821825	3	1	0	0	0	1
20	ZINC000012496524	3	3	0	0	0	1
21	Epacadostat	2	4	0	1	3	1

^aAqueous-solubility level: 0 (extremely low); 1 (very low, but possible); 2 (low); 3 (good).

^bBlood Brain Barrier level: 0 (Very high penetrant); 1 (High); 2 (Medium); 3 (Low); 4 (Undefined).

^cCytochrome P450 2D6 level: 0 (Non-inhibitor); 1 (Inhibitor).

^dHepatotoxicity: 0 (Nontoxic); 1 (Toxic).

^eHuman-intestinal absorption level: 0 (good); 1 (moderate); 2 (poor); 3 (very poor).

^fPlasma Protein Binding: 0 (Absorbent weak); 1 (Absorbent strong).