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NBP attenuated inflammation and brain edema in intracerebral hemorrhage. NBP treatment substantially inhibit the inflammation, reduced ICH-induced brain edema, and then protected the BBB from disruption. BBB: blood-brain barrier; CNS: central nervous system; MMP-9: matrix metalloproteinase-9; NBP: butylphthalide; ROS:reactive oxygen species; TNF-α: tumor necrosis factor-alpha.
