Table 1. Animal characteristics.

	WT			SIRTTG
	Young	Middle-Age	Old	Young	Middle-Age	Old
Male:female N	11:12	12:10	10:4	9:10	11:6	11:10
Age, mo	5.9±0.3	11.6±0.2†	22.9±0.5†‡	5.9±0.4	11.0±0.3†	23.2±0.2†‡
Body mass, g	27±1	31±1†	32±1†	27±1	32±1†	29±1*
Heart, mg	128±3	149±6†	192±8†‡	132±6	146±7	181±5†‡
Heart:body mass, mg/g	4.7±0.1	4.9±0.1	6.0±0.5†‡	4.8±0.2	4.8±0.2	6.3±0.2†‡
Quadriceps, mg	194±7	200±6	171±13‡	202±7	191±10	171±12†
Quadriceps:body mass, mg/g	6.9±0.2	6.6±0.2	5.8±0.4†‡	7.4±0.3	6.4±0.3†	5.6±0.3†
Gastrocnemius, mg	153±7	152±6	159±11	158±7	154±8	153±9
Gastrocnemius:body mass, mg/g	5.5±0.2	5.0±0.2	5.4±0.3	5.7±0.2	5.1±0.2	5.2±0.3
Soleus, mg	12±1	11±0	12±1	11±1	11±1	11±1
Soleus:body mass, mg/g	0.42±0.03	0.38±0.02	0.40±0.03	0.40±0.02	0.36±0.01	0.38±0.02
Liver, g	1.4±0.1	1.5±0.1	2.1±0.1†‡	1.4±0.1	1.6±0.1	2.0±0.1†‡
Spleen, mg	84±6	88±4	179±54†‡	71±4	74±3*	161±22†‡
Perigonadal WAT, mg	417±69	454±53	450±105	446±68	563±63	404±110

*P<0.05 vs. WT. ^†P<0.05 vs. Young. ^‡P<0.05 vs. Middle-Age. Data are mean±SEM.

White adipose tissue, WAT; Wild-type, WT; SIRT-1 transgenic overexpressing, SIRT^TG.