Table 1.
Characteristics of the study variables at baseline and follow-up in Suihua cohort.
| Characteristic | F1 parent generation | F2 offspring generation | ||||
| Non-famine (n=965) | Famine (n=916) | P-Value | Non-famine (n=353) | Famine (n=675) | P-Value | |
| Baseline | ||||||
| Age (years) | 52.7 (2.6) | 53.1 (4.6) | <0.001 | 26.2 (5.2) | 26.4 (4.5) | 0.522 |
| Men [n(%)] | 671 (69.5) | 569(62.1) | 0.325 | 207 (58.6) | 389 (57.6) | 0.237 |
| Energy(kcal/d) | 2445 (1027) | 2468 (1003) | 0.512 | 2537 (845) | 2501 (824) | 0.431 |
| Over high school level [n(%)] | 146 (15.1) | 129 (14.1) | 0.203 | 42 (11.9) | 74 (11.0) | 0.523 |
| Low working strength [n(%)] | 279 (28.9) | 233 (25.4) | 0.032 | 98(27.8) | 162 (24.0) | 0.411 |
| Smoker [n(%)] | 341 (35.3) | 321 (35.0) | 0.851 | 128 (36.3) | 226 (33.5) | 0.151 |
| Drinker [n(%)] | 354 (36.7) | 304 (33.2) | 0.042 | 105 (29.7) | 226 (33.5) | 0.362 |
| Hypertensive [n(%)] | 459 (47.6) | 495 (54.0) | 0.012 | 76 (21.5) | 171 (25.3) | 0.091 |
| Sport [n(%)] | 279 (28.9) | 244 (26.6) | 0.326 | 85 (24.1) | 176 (26.1) | 0.332 |
| BMI (kg/m2) | 24.4 (3.1) | 25.1 (3.2) | 0.439 | 24.1 (4.2) | 25.5 (3.2) | 0.318 |
| FPG (mmol/L) | 4.5 (1.1) | 4.8 (1.1) | 0.021 | 4.3 (0.5) | 4.5 (0.6) | 0.024 |
| 2-hPG (mmol/L) | 6.0 (1.8) | 6.4 (2.6) | 0.016 | 5.1 (1.2) | 5.5 (1.3) | 0.028 |
| SBP (mmHg) | 137.4 (23.3) | 142.1 (21.2) | 0.021 | 124.6 (16.0) | 128.8 (14.1) | 0.020 |
| DBP (mmHg) | 80.3 (13.8) | 83.1 (16.1) | 0.380 | 77.4 (11.0) | 78.0 (10.6) | 0.241 |
| BUN (mmol/L) | 5.4 (1.6) | 5.8 (1.5) | 0.022 | 4.9 (1.3) | 5.1 (1.3) | 0.029 |
| UA (μmol/L) | 284.4 (84.4) | 294.9 (85.0) | 0.022 | 280.1 (87.2) | 284.3 (85.3) | 0.853 |
| CRE (mg/dL) | 0.66 (0.14) | 0.69 (0.18) | 0.014 | 0.67 (0.14) | 0.69 (0.15) | 0.033 |
| eGFR (ml/min/1.73 m2) | 114.5 (30.3) | 100.3 (24.5) | <0.001 | 130.2 (36.3) | 115.0 (29.9) | 0.007 |
| Follow-up | ||||||
| SBP (mmHg) | 139.2 (21.1) | 145.0 (22.3) | <0.001 | 126.9 (20.4) | 132.5 (17.1) | 0.014 |
| DBP (mmHg) | 82.2 (12.0) | 86.0 (17.7) | 0.011 | 77.6 (11.1) | 80.2 (13.9) | 0.332 |
| BUN (mmol/L) | 5.7 (1.4) | 6.2 (1.5) | <0.01 | 5.1 (1.4) | 5.4 (1.5) | 0.017 |
| UA (μmol/L) | 288.4 (80.9) | 300.4 (85.8) | <0.01 | 282.1 (82.5) | 284.3 (85.9) | 0.058 |
| CRE (mg/dL) | 0.67 (0.11) | 0.71 (0.14) | <0.01 | 0.69 (0.17) | 0.73 (0.15) | 0.003 |
| eGFR (ml/min/1.73 m2) | 109.5 (32.8) | 90.2 (28.6) | <0.001 | 118.2 (35.6) | 100.9 (38.1) | 0.001 |
Continuous variables are presented as the mean (SD). Generalized linear mixed models and χ2 test were used to probe for differences in continuous and dichotomous variables. eGFR, estimated glomerular filtration rate. BMI, Body mass index. FPG, Fast plasma glucose. 2-hPG, 2-hour postprandial glucose. SBP, Systolic blood pressure. DBP, Diastolic blood pressure. BUN, blood urea nitrogen. UA, Uric Acid. CRE, serum creatinine.