Table 5.
Associations between F1 prenatal famine exposure and F2 DNA methylation with the mediation of F1 DNA methylation.
| Predictor(F1) | Mediator(F1) | Outcome(F2) | Total effect Estimate,(95% CI) | Proportion via mediation Estimate,% | Sensitivity analysis | |
| R^2* | R^2~ | |||||
| Paternal exposure | cg13528513 | cg13528513 | -0.016 (-0.030 to -0.003) | 28.66 | 0.16 | 0.112 |
| Paternal exposure | cg20906621 | cg20906621 | -0.013 (-0.025 to -0.001) | 25.38 | 0.04 | 0.033 |
| Paternal exposure | cg17160506 | cg17160506 | -0.018 (-0.028 to -0.008) | 30.98 | 0.09 | 0.067 |
| Maternal exposure | cg13528513 | cg13528513 | -0.020 (-0.032 to -0.009) | 29.31 | 0.09 | 0.066 |
| Maternal exposure | cg20906621 | cg20906621 | -0.031 (-0.048 to -0.014) | 32.65 | 0.16 | 0.112 |
| Maternal exposure | cg17160506 | cg17160506 | -0.023 (-0.030 to -0.015) | 29.97 | 0.09 | 0.067 |
The predictor is F1 prenatal exposure to famine, the mediator is F1 DNA methylation, and the outcome is F1 ΔeGFR. R^2*, the proportion of residual variances. R^2~, the proportion of original variances that were explained by the omitted confounding