Table 6.
Associations between F1 parental prenatal famine exposure and F2 ΔeGFR in adulthood with the mediation of F2 DNA methylation.
| Predictor(F1) | Mediator(F2) | Outcome(F2) | Total effect Estimate, (95% CI) | Proportion via mediation Estimate,% | Sensitivity analysis | |
| R^2* | R^2~ | |||||
| Paternal exposure | cg13528513 | ΔeGFR | -0.05 (-0.09 to -0.02) | 8.77 | 0.16 | 0.112 |
| Paternal exposure | cg20906621 | ΔeGFR | -0.13 (-0.23 to -0.03) | 11.47 | 0.16 | 0.112 |
| Paternal exposure | cg17160506 | ΔeGFR | -0.10 (-0.17 to -0.03) | 8.60 | 0.09 | 0.066 |
| Maternal exposure | cg13528513 | ΔeGFR | -0.11 (-0.17 to -0.05) | 8.13 | 0.09 | 0.067 |
| Maternal exposure | cg20906621 | ΔeGFR | -0.09 (-0.16 to -0.01) | 10.10 | 0.09 | 0.067 |
| Maternal exposure | cg17160506 | ΔeGFR | -0.06 (-0.09 to -0.03) | 9.10 | 0.09 | 0.066 |
The predictor is F1 prenatal exposure to famine, the mediator is F1 DNA methylation, and the outcome is F1 ΔeGFR. R^2*, the proportion of residual variances. R^2~, the proportion of original variances that were explained by the omitted confounding