Table 4.
Sensitivity analysis: adjusted associations of FPG, 2-hr PPPG, GDM status (according to WHO 1999 definition) at 26 weeks’ gestation with cIMT, cfPWV, AIx, AIx@75 SBP and DBP at age 6 years excluding preterm children or mothers with GDM or children with negative AIxa
SBP, mmHg n = 452 |
DBP, mmHg n = 452 |
|||
---|---|---|---|---|
β [CI 95%] | β [CI 95%] | |||
Unadjusted | Adjusteda | Unadjusted | Adjusteda | |
FPG, mmol/L | 1.75 [0.13; 3.37]b | 1.52 [-0.23; 3.26] | 0.09 [-1.12; 1.30] | 0.17 [-1.16; 1.50] |
2-hr PPPG, mmol/L | -0.15 [-0.66; 0.37] | -0.02 [-0.58; 0.54] | -0.41[-0.79; -0.03]b | -0.36 [-0.78; 0.07] |
GDMc | 0.48 [0.04 ; 0.92]b | 0.66 [-1.36; 2.69] | -0.10 [-0.42 ; 0.23] | 0.20 [-1.33; 1.73] |
Multiple linear and logistic regressions on multiple imputed datasets (n=20) also adjusted for study center, child’s sex, paternal height, maternal characteristics (ethnicity, age at delivery, height, pre-pregnancy BMI, educational attainment, BP category before 20 weeks of gestation, active smoking status at 26 weeks of gestation, exposure to tobacco at home and/or work in early pregnancy and at 26 weeks).
P-value<0.05.
GDM defined using WHO 1999 criteria.
Abbreviations: cIMT: carotid intima media thickness, cfPWV: carotid femoral pulse wave velocity, AIx: augmentation index, AIx@75: augmentation index normalized to a heart rate of 75 beats/min, SBP: systolic blood pressure, DBP: diastolic blood pressure, FPG: fasting plasma glucose, PPPG: postprandial plasma glucose, GDM: gestational diabetes mellitus.