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. Author manuscript; available in PMC: 2020 Jul 8.
Published in final edited form as: J Am Chem Soc. 2020 Mar 16;142(13):6268–6284. doi: 10.1021/jacs.0c00484

Table 1.

Simulated Kinetic Constants Based on the 3-Step Kinetic Model.

Substrate k1 (mM−1 s−1) k2 (s−1) k3 (s−1)
2-H ~14 33 0.1
2-F ~12 28 0.15
2-OMe ~12 42 0.20
2-CF3 ~30 12 1.2