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. 2020 May 5;7(5-6):30–33. doi: 10.18632/oncoscience.504

Figure 1. 4T1 in-vivo mouse model shows the pro-metastatic nature of HUNK in breast cancer.

Figure 1

4T1 breast cancer cells were injected in the mammary glands of mice then monitored for their tumor growth and metastasis. It was found that HUNK’s direct phosphorylation of EGFR at T654 promotes epithelial mesenchymal transition, leading to cancer metastasis.