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Age distributions for PAH cases from the National Biological Sample and Data Repository for PAH (n=2572). BMPR2, TBX4 and SOX17 variant carriers have younger mean age-of-onset compared to the whole cohort with significant enrichment of pediatric-onset cases among TBX4 variant carriers compared to the whole cohort (Zhu et al 2019 #8). Red vertical lines indicate the group means.
