Table 5 |.
Polygenic risk scores and vascular outcomes
| Outcome type | Outcome | T2D PRSdecile | n Cases | n Controls | OR | 95%CI lower | 95%CI upper | P | P forlinear trend |
|---|---|---|---|---|---|---|---|---|---|
| Vascular | Coronary heart disease | 0–10% | 2,913 | 3,924 | 1.00 | Ref | Ref | - | 0.636 |
| 10–20% | 2,940 | 3,924 | 1.01 | 0.92 | 1.12 | 0.811 | |||
| 20–30% | 2,958 | 3,924 | 0.98 | 0.89 | 1.08 | 0.742 | |||
| 30–40% | 2,934 | 3,924 | 0.99 | 0.90 | 1.09 | 0.835 | |||
| 40–50% | 2,988 | 3,924 | 1.01 | 0.92 | 1.11 | 0.801 | |||
| 50–60% | 3,001 | 3,924 | 0.98 | 0.90 | 1.08 | 0.744 | |||
| 60–70% | 2,977 | 3,924 | 1.01 | 0.92 | 1.10 | 0.887 | |||
| 70–80% | 2,916 | 3,924 | 1.02 | 0.93 | 1.12 | 0.632 | |||
| 80–90% | 3,032 | 3,924 | 0.96 | 0.88 | 1.05 | 0.391 | |||
| 90–100% | 3,038 | 3,924 | 1.03 | 0.94 | 1.12 | 0.537 | |||
| Acute ischemic stroke | 0–10% | 555 | 6,027 | 1.00 | Ref | Ref | - | 0.070 | |
| 10–20% | 563 | 6,027 | 0.90 | 0.76 | 1.07 | 0.238 | |||
| 20–30% | 583 | 6,027 | 0.98 | 0.83 | 1.15 | 0.782 | |||
| 30–40% | 619 | 6,027 | 0.98 | 0.84 | 1.15 | 0.821 | |||
| 40–50% | 530 | 6,027 | 0.99 | 0.85 | 1.16 | 0.924 | |||
| 50–60% | 576 | 6,027 | 0.99 | 0.85 | 1.16 | 0.941 | |||
| 60–70% | 645 | 6,027 | 0.97 | 0.83 | 1.13 | 0.672 | |||
| 70–80% | 590 | 6,027 | 1.04 | 0.90 | 1.20 | 0.611 | |||
| 80–90% | 558 | 6,027 | 1.05 | 0.91 | 1.22 | 0.494 | |||
| 90–100% | 627 | 6,027 | 1.02 | 0.89 | 1.17 | 0.784 | |||
| Peripheral artery | 0–10% | 1,966 | 4,871 | 1.00 | Ref | Ref | - | 2.0E-07 | |
| disease | 10–20% | 1,964 | 4,871 | 1.00 | 0.93 | 1.08 | 0.927 | ||
| 20–30% | 1,948 | 4,871 | 1.01 | 0.93 | 1.08 | 0.890 | |||
| 30–40% | 1,984 | 4,871 | 1.04 | 0.96 | 1.12 | 0.361 | |||
| 40–50% | 1,964 | 4,871 | 1.03 | 0.96 | 1.11 | 0.425 | |||
| 50–60% | 1,950 | 4,871 | 1.02 | 0.95 | 1.10 | 0.559 | |||
| 60–70% | 1,972 | 4,871 | 1.05 | 0.98 | 1.14 | 0.165 | |||
| 70–80% | 1,960 | 4,871 | 1.05 | 0.97 | 1.13 | 0.203 | |||
| 80–90% | 2,019 | 4,871 | 1.10 | 1.02 | 1.19 | 0.010 | |||
| 90–100% | 2,102 | 4,871 | 1.20 | 1.11 | 1.29 | 1.9E-06 |
Genome-wide polygenic risk scores (gPRS) for T2D were generated in the MVP participants of European ancestry with T2D by calculating a linear combination of weights derived from the Europeans in the DIAMANTE Consortium using the prune and threshold method in PRSice-2 software (pruning r2 = 0.8, P = 0.05). The gPRSs were divided into deciles and the risk of T2D-related vascular outcomes was assessed using a logistic regression model using the lowest decile (0–10%) as the reference category, together with the potential confounding factors of age, gender, and the first 10 PCs of European ancestry. The decile-specific P-values are shown in the column labeled P. In a separate logistic regression analysis, the continuous PRS was set as the dependent variable together with age, gender, and the first 10 PCs, and the P-value for linear trend is shown in the column labeled P for linear trend. For coronary heart disease, a CHD PRS (from CardiogramplusC4DplusUKBB) is included in the regression model as an additional covariate. For acute ischemic stroke, a stroke PRS (from MEGASTROKE consortium) is included in the regression model as an additional covariate. T2D, type 2 diabetes; PRS, polygenic risk score; n Cases, number of cases with the respective vascular outcome; n Controls, number of unaffected controls for the respective vascular outcome; OR, odds ratio; CI, confidence interval.