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. Author manuscript; available in PMC: 2021 Jul 15.
Published in final edited form as: J Immunol. 2020 Jun 5;205(2):502–510. doi: 10.4049/jimmunol.2000037

Figure 1. NK cells in 3xTg-AD mice exhibited an enhanced pro-inflammatory profile.

Figure 1.

A, Representative flow cytometry profiles of NK cells in 7–8 months 3xTg-AD and control mice. Plots were pre-gated on brain CD45+CD3−B220− lymphocytes. B, Numbers of NK cells in 7–8 months 3xTg-AD and control mice. C, UMAP analysis of sorted NK cells in 7 month old 3xTg-AD and control mice by single-cell RNA-seq (scRNA-seq). D, Expression of individual genes in sorted NK cells by scRNA-seq. E, Pathways of genes highly expressed in NK1AD subset. F, List of presentative genes highly expressed in NK1AD subset. G, Violin plots depicting expression of the indicated genes in each NK cell subsets. H, Expression of the indicated genes in NK1a and NK1b subsets in 3xTg-AD and control mice. Data are from 6 mice per group, pooled from two independent experiments (A and B), or are pooled from 6 mice per group (C-G). *p<0.05; **p<0.01.