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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: FEBS J. 2020 Jan 23;287(15):3235–3254. doi: 10.1111/febs.15207

Figure 6: Interactions of Loop 2 tip and comparison of three highly resistant mutants PRS5B, PRS17, and PR20 with wild-type PR.

Figure 6:

A. B-subunit beta-loop of Loop 2 (residues 67–69) interacting with Loop 1 (residues 24 and 11–14 shown) and the C-terminus of A subunit. PRS5B/APV is shown in cyan sticks. PR/APV is grey sticks. Hydrogen bonds and ion-pair are shown as dashed lines. Distances in Å are indicated as orange arrows. B. PRS5B Loop 2 tip comparison with drug resistant mutants PRS17 and PR20. Protease/DRV cartoon complexes colored as follows: Wild-type PR (grey), PRS5B (cyan), PRS17 (green), and PR20 (magenta). Side chains for tip residues and interacting residues, including PRS5B mutations L24M and V11I are shown as sticks. Structure figures were generated using PyMOL.