Figure 3. Infiltration and repertoire diversity combine to describe prognosis.

(A) The ratio of CD3 infiltration to TIL clone diversity defines monoclonal versus polyclonal individual repertoire distributions. (B) Representative histograms in which each line reflects a unique TCR clone; clones are ordered by descending frequency on a log scale. Color summarizes both degree of infiltration and repertoire diversity. Low levels of infiltration relative to clone diversity are associated with poor prognosis by (C) PFS and (D) OS. 1-Entropy is a measure of clonality; clones are unique amino acid sequences; reads are counts of a given clone.