Table 2. Prognostic features of the ovarian cancer TCR repertoire.
| Hazard Ratio (95% CI, Cox Model) | ||
|---|---|---|
| PFS | OS | |
| Infiltration* | ||
| CD3 (log lym/mm2) | 0.59 (0.43–0.83) | 0.49 (0.33–0.72) |
| CD8 (log lym/mm2) | 0.57 (0.37–0.86) | 0.46 (0.28–0.77) |
| Focus: Diversity/TIL* | ||
| #Clones/CD3 | 5.32 (1.98–14.30) | 5.46 (2.03–14.66) |
| #Clones/CD8 | 4.14 (0.53–32.37)N/S | 17.49 (1.59–***) |
| Overlap** | ||
| Clones | 1.35 (1.06–1.72) | 1.41 (1.10–1.80) |
| Reads | 1.04 (0.78–1.38)N/S | 1.27 (0.94–1.71)N/S |
| Diversity Ratio** | ||
| PBMC/TIL | 0.73 (0.55–0.97) | 1.01 (0.74–1.39)N/S |
All factors scaled to unit standard deviation. *Stage adjusted, **CD3 adjusted, ***Upper bound omitted due to size, N/SNot significant (p > 0.05).