Table 3. T cell receptor properties stratified by stage and infiltration.
| A. Low Stage N = 22 | B. High Stage High Infiltration N = 38 | C. High Stage Low Infiltration N = 39 | p-value (A vs. B, C) | p-value (B vs C) | |
|---|---|---|---|---|---|
| Clonality (1-Norm. Entropy) | |||||
| TIL | 0.189 | 0.204 | 0.210 | 0.827 | 0.455 |
| PBMC | 0.095 | 0.078 | 0.087 | 0.875 | 0.234 |
| Diversity (Median #Clones) | |||||
| TIL | 2,828 | 11,549 | 7,317 | 0.003 | 0.136 |
| PBMC | 86,190 | 94,513 | 65,561 | 0.845 | 0.019 |
| Depth (Median #Reads) | |||||
| TIL | 511,068 | 2,791,190 | 1,864,132 | 0.069 | 0.132 |
| PBMC | 3,651,511 | 3,877,524 | 3,468,589 | 0.582 | 0.267 |
| Focus: Diversity/TIL | |||||
| #Clones/CD3 | 1.80 | 1.53 | 2.80 | 0.929 | < 0.001 |
| #Clones/CD8 | 3.28 | 1.95 | 22.72 | 0.645 | < 0.001 |
| #Clones/CD4 | 7.80 | 6.83 | 7.49 | 0.330 | 0.048 |