Table 3.
Comparison of plasma and serum based anti-SARS-CoV-2 antibody detection.
Epitope |
Euroimmun |
Roche |
|||||
---|---|---|---|---|---|---|---|
Plasma |
Serum |
Plasma |
Serum |
Plasma |
Serum |
||
Absolute result | Mean | 0.90 | 0.90 | 4.00 | 4.40 | 14.00 | 7.50 |
Range | −0.01–1.48 | −0.023–1.48 | 0.35–8.63 | 0.35–9.69 | 0.08–56.7 | 0.08–42.7 | |
Median | 1.30 | 1.40 | 2.60 | 4.50 | 8.40 | 1.40 | |
Kendalĺs tau | 0.82 | 0.77 | 0.60 | ||||
Mean bias (95% CI) | −11.65% (-36.13% − 12.83%) | 23.12% (-8.61% − 54.85%) | −28.57% (-45.18% - −11.96%) | ||||
Interpreted result | Overall Agreement (%) | 100.00 | 90.0*/95.0# | 100.00 | |||
Positive Agreement (%) | 100.00 | 92.3*/100# | 100.00 | ||||
Negative Agreement (%) | 100.00 | 85.7*/87.5# | 100.00 | ||||
Coheńs kappa | 1.00 | 0.78 (0.49–1.07)*/0.89 (0.69–1.10)# | 1.00 |