Table 2.
Mean (SD) |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Day 1 | Day 8 | Day 15 | Day 22 | Day 29 | Day 36 | Day 43 | Day 71 | Day 99 | Day 127 | |
Alopecia | 92.4 | 93.7 | 93.5 | 93.6 | 91.5 | 90.1 | 88.3 | 82.8 | 79.9 | 75.0 |
(18.4) | (16.5) | (16.5) | (17.5) | (17.9) | (18.0) | (21.7) | (26.6) | (28.5) | (30.6) | |
Dry skin | 94.4 | 90.1 | 82.1 | 83.6 | 86.3 | 88.3 | 86.6 | 85.0 | 84.5 | 85.6 |
(8.7) | (13.9) | (21.7) | (19.3) | (16.9) | (11.5) | (12.6) | (16.1) | (13.4) | (17.4) | |
Hypertrichosis | 96.7 | 96.1 | 94.3 | 95.4 | 97.4 | 97.3 | 95.8 | 87.8 | 91.7 | 86.4 |
(11.1) | (13.8) | (17.4) | (11.9) | (8.6) | (8.9) | (12.4) | (23.6) | (22.4) | (24.3) | |
Pain of skin | 95.5 | 86.6 | 76.1 | 79.9 | 82.4 | 86.9 | 82.7 | 83.0 | 85.4 | 84.3 |
(11.4) | (18.4) | (23.7) | (22.7) | (20.0) | (12.2) | (16.9) | (18.5) | (16.6) | (18.5) | |
Paronychia | 96.2 | 95.2 | 92.5 | 87.7 | 86.8 | 88.0 | 82.4 | 77.2 | 80.2 | 75.8 |
(9.9) | (10.3) | (14.2) | (20.6) | (20.3) | (16.4) | (22.6) | (25.3) | (26.3) | (24.6) | |
Pruritus | 92.8 | 83.0 | 74 | 76.5 | 78.8 | 84.9 | 79.1 | 80.6 | 79.2 | 81.4 |
(15.1) | (22.4) | (24.2) | (23.4) | (21.4) | (12.8) | (18.3) | (18.6) | (19.4) | (20.5) | |
Rash | 94.9 | 89.5 | 80.7 | 82.8 | 85.5 | 88.5 | 85.2 | 84.4 | 84.3 | 84.7 |
(8.2) | (13.9) | (20.7) | (18.9) | (15.8) | (9.7) | (13.1) | (16.6) | (14.5) | (16.9) | |
Total FACT- EGFRI 18 | 67.9 | 64.9 | 60.1 | 60.8 | 62.1 | 63.8 | 61.5 | 60.1 | 60.0 | 59.6 |
(5.3) | (8.1) | (11.8) | (10.8) | (9.0) | (6.0) | (8.6) | (11.0) | (9.9) | (11.6) |
*Higher FACT-EGFRI scores reflect better health-related quality of life