Table 1.
Correspondence between kinfitr and PMOD
| Pearson’s r | ICC | Bias (%) | |||||
|---|---|---|---|---|---|---|---|
| Ligand | Model | Region 1 | Region 2 | Region 1 | Region 2 | Bias 1 | Bias 2 |
| Invasive | |||||||
| [11C]PBR28 | 2TCM | 1.00 | 1.00 | 0.99 | 1.00 | 2.01 | 1.19 |
| Logan | 1.00 | 1.00 | 0.99 | 0.99 | 0.47 | − 0.27 | |
| MA1 | 1.00 | 0.99 | 0.95 | 0.97 | 10.07 | 9.55 | |
| [11C]PK11195 | 2TCM | 1.00 | 0.98 | 1.00 | 0.98 | 1.16 | 0.69 |
| Logan | 1.00 | 0.97 | 0.99 | 0.94 | − 3.40 | − 5.88 | |
| MA1 | 0.99 | 0.95 | 0.97 | 0.89 | 4.99 | 9.54 | |
| Non-invasive | |||||||
| [11C]AZ10419369 | SRTM | 1.00 | 1.00 | 1.00 | 1.00 | -0.17 | 0.13 |
| ref Logan | 0.99 | 0.99 | 0.93 | 0.91 | − 2.95 | − 3.55 | |
| MRTM2 | 0.97 | 0.96 | 0.86 | 0.80 | − 3.94 | − 5.35 | |
| [11C]SCH23390 | SRTM | 1.00 | 1.00 | 1.00 | 1.00 | 0.24 | 0.53 |
| ref Logan | 0.99 | 0.99 | 0.88 | 0.96 | − 5.26 | − 4.31 | |
| MRTM2 | 1.00 | 1.00 | 0.98 | 0.99 | − 2.07 | − 2.17 | |
Region 1 corresponds to the occipital cortex for the radioligand [11C]AZ10419369, the striatum for [11C]SCH23390 and the thalamus for both (R)-[11C]PK11195 and [11C]PBR28. Region 2 corresponds to the frontal cortex for all four radioligands which were used in this study. Abbreviations: 2TCM two-tissue compartmental model, Logan invasive Logan plot, MA1 Ichise’s Multilinear Analysis 1, SRTM simplified reference tissue model, ref Logan reference tissue Logan plot, MRTM2 Ichise's Multilinear Reference Tissue Model 2 (MRTM2), ICC intra-class correlation coefficient, Pearson’s r Pearson’s correlation coefficient