TABLE 1.

Classifications of PLY-induced cell death pathways.

Cell death	Affected tissue	References
Apoptosis	Cochlear hair cells	Beurg et al., 2005
	Cortical neurons	Braun et al., 2002, 2007
	Dendritic cells	Littmann et al., 2009
Necroptosis	Respiratory epithelium	Gonzalez-Juarbe et al., 2017
	Alveolar macrophages	Riegler et al., 2019
Direct cytotoxicity	Lung endothelium	Rubins et al., 1992
	Nasal/tracheobronchial epithelium	Steinfort et al., 1989;Rayner et al., 1995
	Polymorphonuclear leukocytes	Johnson et al., 1981
	Platelets	Johnson et al., 1981
	Cardiomyocytes	Alhamdi et al., 2015
	Brain microvascular endothelium	Zysk et al., 2001
	Ependymal cells	Mohammed et al., 1999; Hirst et al., 2000b