TABLE 1.

Summary statistics of data source.

Traits	Consortium	Data sources	No. of participants	No. of Variants	Population	Units in TSMR
WHR	ZENODO	Censin; PloS Genet; 2019	697,734	27,381,301	European	SD
BMI	ZENODO	Censin; PloS Genet; 2019	806,834	27,376,273	European	SD
WHRadjBMI	ZENODO	Censin; PloS Genet; 2019	694,649	27,375,636	European	SD
HDL-C	MRBase	Kettunen; Nat Commun; 2016	21,555	11,865,530	European	SD
LDL-C	MRBase	Kettunen; Nat Commun; 2016	21,559	11,871,461	European	SD
SBP	MRC-IEU	Ben Elsworth; 2018	436,419	9,851,867	European	SD
DBP	MRC-IEU	Ben Elsworth; 2018	436,424	9,851,867	European	SD
Fasting glucose	MAGIC	Manning, Nat Genet; 2012	58,074	2,628,880	European	mmol/L
Fasting insulin	MAGIC	Manning, Nat Genet; 2012	51,750	2,627,849	European	log pmol/L
HOMA-IR	MAGIC	Dupuis; Nat Genet; 2010	37,037	2,458,074	European	log HOMA
HbA1c	MAGIC	Wheeler, PloS Med; 2017	123,655	2,586,698	European	%
T2DM	Program in Complex Trait Genomics	Xue; Nat Commun; 2018	62,892/596,424	5,053,015	European	log odds

WHR, waist-to-hip ratio; BMI, body mass index; WHRadjBMI, waist-to-hip ratio adjusted for body mass index; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SBP, systolic blood pressure; DBP, diastolic blood pressure; T2DM, Type 2 diabetes; TSMR, two-sample Mendelian randomization; SD, standard deviation; HOMA-IR, Homeostasis model assessment of insulin resistance; HbA1c, Hemoglobin A1c.