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. 2020 Jul 2;11:1498. doi: 10.3389/fmicb.2020.01498

TABLE 2.

Rhodamine 6G efflux in BBH and FLC-treated C. albicans.

CA 0253 Time of drug action
0 min 10 min 30 min 60 min 2 h
BBH + FLC◆★▲ 1069 ± 131 2472 ± 117 8596 ± 305 16892 ± 310 26019 ± 663
FLCInline graphic▲ 1107 ± 169 2172 ± 101 12761 ± 69 21579 ± 982 38365 ± 1132
BBH▲ 1466 ± 242 2946 ± 170 15366 ± 902 20047 ± 696 33294 ± 293
Control 932 ± 15 2782 ± 143 16502 ± 813 26887 ± 153 39751 ± 705

CA 0253 were treated with BBH (2 μg/mL) plus FLC (1 μg/mL), FLC (1 μg/mL), BBH (2 μg/mL), or RPMI-1640 medium. After drug treatment, fluorescence intensity was detected (emission wavelength 530 nm) at 0, 10, 30, 60, and 120 min. Three independent experiments were performed, with eight replicates in each group (n = 8). Values represent means ± SEM. ANOVA tested statistical differences. ◆ compared with the FLC group, p < 0.05; ★ compared with the BBH group, p < 0.05; ▲compared with the control group, p < 0.05; Inline graphic compared with the BBH group, p > 0.05.