Table 1.
Results of the antibody dose-escalation study in RD-ES tumor-bearing mice, sacrificed 24 h after radiopharmaceutical injection. Organ uptake values (mean %IA/g ± SD) are shown for different amounts of total antibody injected (range: 0.2–1000 μg)
| Source organ (%IA/g) |
0.2 μg AB | 5 μg AB | 25 μg AB | 50 μg AB | 200 μg AB | 1000 μg AB | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Blood | 0.189 | 0.041 | 0.204 | 0.032 | 1.634 | 1.004 | 3.274 | 1.939 | 10.777 | 2.219 | 9.092 | 0.688 |
| Liver | 33.404 | 0.492 | 39.580 | 1.646 | 15.905 | 3.289 | 10.656 | 0.955 | 14.034 | 5.203 | 13.078 | 1.915 |
| Spleen | 114.131 | 27.447 | 125.320 | 2.422 | 32.636 | 4.632 | 23.480 | 7.554 | 10.944 | 0.988 | 5.781 | 0.794 |
| Heart | 1.508 | 0.391 | 2.844 | 0.183 | 1.608 | 0.307 | 1.669 | 0.479 | 3.853 | 1.017 | 3.409 | 0.084 |
| Kidneys | 10.449 | 0.100 | 14.499 | 0.867 | 11.496 | 2.318 | 9.157 | 0.955 | 11.254 | 2.609 | 8.966 | 1.310 |
| Lungs | 3.392 | 0.452 | 4.849 | 0.296 | 5.290 | 2.724 | 3.739 | 0.779 | 6.681 | 0.557 | 4.884 | 0.703 |
| Uterus and ovaries | 2.155 | 0.618 | 3.604 | 1.359 | 5.587 | 2.015 | 5.716 | 1.497 | 6.966 | 1.869 | 5.813 | 1.598 |
| Stomach | 0.818 | 0.631 | 0.861 | 0.379 | 1.161 | 0.438 | 0.853 | 0.148 | 1.230 | 0.274 | 0.934 | 0.191 |
| Pancreas | 0.206 | 0.115 | 0.399 | 0.000 | 1.423 | 0.194 | 1.193 | 0.200 | 1.781 | 0.465 | 1.257 | 0.322 |
| Small intestine | 1.387 | 0.082 | 4.477 | 1.078 | 5.349 | 0.639 | 3.610 | 0.359 | 2.239 | 0.285 | 1.589 | 0.418 |
| Colon | 0.791 | 0.007 | 2.976 | 0.374 | 2.932 | 0.602 | 2.909 | 0.680 | 2.762 | 0.572 | 2.665 | 1.469 |
| Muscle | 0.198 | 0.019 | 0.203 | 0.025 | 0.541 | 0.172 | 0.628 | 0.225 | 0.980 | 0.540 | 0.994 | 0.088 |
| Tumor | 1.288 | 0.221 | 7.423 | 3.760 | 9.436 | 1.986 | 6.979 | 0.949 | 6.435 | 1.275 | 4.186 | 0.067 |