Table 1.

List of cell-/organ-specific deficient mice for IL-1 isoforms or their receptors and main effects observed

Gene	Cre driver	Cell/tissue targeted	Main effects	References
Il1a	Myh6-Cre	Cardiomyocytes	No effect on cardiac tissue remodeling after MI	Bageghni et al. [40]
Il1b	CMV-Cre	Ubiquitous deletion	Reduces bone metastasis during breast cancer	Tulotta et al. [47]
	CX3CR1-CreER	Microglial cell	Reduces the development of pain	[39]
Il1r1	K14-Cre	Ubiquitous deletion	Mediates peripheral immune response to T. Muris infection	[42]
			Inhibits melanoma inflammatory niche	Young et al. [48]
	CMV-Cre	Ubiquitous deletion	Decreases inflammatory responses to systemic challenges	Mufazalov et al. [49]; Mufazalov et al. [50]
			NI	Robson et al. [41]
	PGK-Cre	Ubiquitous deletion	Regulates cardiac tissue remodeling after MI	Bageghni et al. [40]
	Col1a2-CreER	Fibroblasts	Regulates cardiac tissue remodeling after MI	Bageghni et al. [40]
	CD4-Cre	T cells	Regulates immune response to CD3 antibody injection	Mufazalov et al. [49]
			Regulates neuroinflammation in EAE	Mufazalov et al. [50]
	Vav-Cre	Myeloid cells	Mediates peripheral immune response to T. Muris infection	Adbulaal et al. [42]
	Ly6G-Cre	Neutrophils	Reduces the tumorigenic effect of IL-1	Dmitrieva-Posocco et al. [51]
	Csf2-Cre	GM-CSF positive cells	Regulates inflammation after EAE	Komuczki et al. [52]
	CX3CR1-CreER	Microglial cells	Reduces renewal of microglial population	Bruttger et al. [53]
			Regulates microglial activation after CNS inflammation	Zhu et al. [54]*
			No effect on febrile response to IL-1	Knoll et al. [55]*
	Myh11-CreER	Smooth muscle cells	Reduces atheroprotective effect of IL-1 after atherosclerosis	Gomez et al. [56]
	Pdx1-Cre	Pancreatic cells	Alters glucose homeostasis and triggers β-cell de-differentiation	Burke et al. [57]
	Slco1c1-CreER	Brain endothelial cells	Reduces CNS inflammation and brain damage after stroke	Wong et al. [58]
			Reduces fever response to IL-1	Matsuwaki et al. [59]
	Nestin-Cre	Neuronal cells	No effect on febrile response to IL-1	Matsuwaki et al. [59]
			Reduces brain damage after stroke	Wong et al. [58]
	Trpv1-Cre	Nociceptor sensory neurons	No effect on febrile response to IL-1	Matsuwaki et al. [59]
	htPA-Cre	Neural crest cells	No effect on febrile response to IL-1	Matsuwaki et al. [59]
	ChAT-Cre	Catecholaminergic neurons	Decreases brain damage after stroke	Wong et al. [58]
	PF4-Cre	Platelets	No effect on brain damage after stroke	Wong et al. [58]
	ColVI-CreER	Intestinal mesenchymal cells	No effect on development of intestinal cancer	Koliaraki et al. [60]
	Hep-Cre	Hepatocytes	Reduces liver injury after acute liver failure	Gehrke et al. [61]
	CD45-Cre	Leukocytes	No role in IL-1-mediated resistance to Mycobacterium tuberculosis	Bohrer et al. [62]
	Cdh5-Cre	Vascular endothelial cells	Mediates the anti-tumor properties of T cells. Regulates IL-1-induced brain inflammation	Lee et al. [63]
	Tie2-Cre	Endothelial cells	Decreases IL-1-induced brain inflammation	Liu et al. [44]#
Il1r2	CMV-Cre	Ubiquitous deletion	Reduces inflammation after arthritis	Martin et al. [45]
	K14-Cre	Ubiquitous deletion	NI	Unpublished**

For IL-1R1^fl/fl mice, all cell-/tissue-specific IL-1R1^−/− mice have been generated by IL-1R1^fl/fl mouse from Abdulaal et al. [42], except those marked (*), generated by IL-1R1^fl/fl mouse from Robson et al. [41]. #In the study of Liu and collaborators (2019), the following mouse lines have also been generated: IL-1R1^fl/fl x LysM-Cre, IL-1R1^fl/fl x CX3CR1-Cre, IL-1R1^fl/fl x Camk2a-Cre, IL-1R1^fl/fl x Vglut2-Cre, and IL-1R1^fl/fl x GFAP-Cre. **IL-1R2^fl/fl mice crossed with K14-Cre mice are reported in the present publication. Cre, constitutive deletion by Cre drivers; Cre-ER, inducible deletion by Cre-ER drivers; EAE, experimental autoimmune encephalomyelitis; MI, myocardial infarction; NI, not indicated