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. 2020 Feb 21;22(4):1021–1030. doi: 10.1007/s11307-020-01481-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1. — a Representative HPLC chromatogram of [⁶⁴Cu]NOTA-CD8a. b Overlay of Coomassie staining and radiography of SDS-PAGE gel. Lane 1, full length CD8a⁺ antibody; lane 2, reduced full length CD8a⁺ antibody; lane 3, [⁶⁴Cu]NOTA-CD8a. cIn vivo biodistribution of [⁶⁴Cu]NOTA-CD8a in major organs derived from PET ROI analysis of the heart, kidney, liver, muscle, and spleen and expressed as % ID/g at 1, 3, 6, 24, and 48 h p.i. (N = 4). d Mean and maximum uptake of [⁶⁴Cu]NOTA-CD8a in tumors derived from PET ROI analysis and expressed as % ID/g (N = 4). eEx vivo biodistribution after the last imaging session 48 h p.i. of [⁶⁴Cu]NOTA-CD8a derived from gamma counting of tissues and expressed as %ID/g (N = 4). Data are presented as mean ± SEM. ALN, axillary lymph node; ILN, inguinal lymph node; CLN, cervical lymph node; % ID/g, % injected dose per gram tissue.