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. 2020 Mar 14;154(1):55–75. doi: 10.1007/s00418-020-01861-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Distribution of CD38⁺⁺ PCs and pericapillary FDCs in tonsil GCs. a–c Staining for CD38⁺⁺ PCs (mAb SPC32, brown) followed by visualisation of CD271⁺ FDCs (mAb EP1039Y, blue). PCs may accumulate in the basal light zone and/or distribute evenly in the light zone and occur at the surface of the GC. They also form rows of cells at the dark zone surface, which are connected to PC clusters in the lamina propria outside the GC (arrows). The basal layer of the crypt epithelium is also CD271⁺. d FDCs at the surface of intra-GC microvessels (arrows) prevent CD20⁺ B lymphocytes (mAb L26, blue) from approaching the endothelium. e The unstained cells in d are CD271⁺, when CD20 is demonstrated in blue (mAb L26) followed by CD271 in brown (mAb EP1039Y). f The nuclei of the pericapillary FDCs (arrows) are also visible in routine HE-stained sections. mz mantle zone, lz light zone of GC, dz dark zone of GC. a, b 21-year-old female. c 12-year-old female. d, e 38-year-old female. f 57-year-old male. Scale bars 100 µm (a, c), 70 µm (b, e), 20 µm (d, f)