Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 14;154(1):55–75. doi: 10.1007/s00418-020-01861-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — PCs in lymph node and spleen GCs. a Single staining for CD38 in a follicle of a cervical lymph node. The distribution of CD38⁺⁺ PCs is similar to that in tonsils (compare Fig. 4a). lz light zone of GC, dz dark zone of GC. The mantle zone cannot be delineated. b Double staining for CD3 (dark blue) and CD27 (brown) in an adult human spleen. This method is optimal to visualise all regions of typical degenerated secondary follicles in normal human spleens (Steiniger et al. 2005, 2006). The follicle consists of a very small GC populated by CD27⁺⁺ PCs and T cells (arrow), a broad inner mantle zone (imz, unstained), and a CD27⁺ memory B-cell zone (memz), which consists of the outer mantle zone and a superficial zone (not visualised in detail). Major numbers of T cells also occur in the superficial zone. Asterisks indicate a follicular artery. a 58-year-old male. b 21-year-old female. Scale bars 200 µm (a), 100 µm (b)