Table 1.
Characteristics of the overall subjects and subjects in the three tertile groups for urinary pteridine level.
| Variable | Overall subjects | Pteridines | ||
|---|---|---|---|---|
| 1st tertile | 2nd tertile | 3rd tertile | ||
| Number | 258 | 86 | 86 | 86 |
| Age (years) | 45.8 ± 8.1 | 44.0 ± 7.2 | 45.8 ± 8.3 | 47.6 ± 8.3* |
| Smokers (%) | 43.4 | 30.2 | 34.9 | 65.1**,†† |
| Drinkers (%) | 66.3 | 68.6 | 65.1 | 65.1 |
| Regular exercise (%) | 18.6 | 22.1 | 17.4 | 16.3 |
| Therapy for hypertension (%) | 9.7 | 12.8 | 11.6 | 4.7 |
| Therapy for dyslipidemia (%) | 4.7 | 4.7 | 9.3 | 0†† |
| Therapy for diabetes mellitus (%) | 2.3 | 1.2 | 2.3 | 3.5 |
| Body mass index (kg/m2) | 23.2 ± 3.1 | 23.1 ± 3.2 | 23.6 ± 3.0 | 23.0 ± 2.9 |
| Systolic blood pressure (mmHg) | 117.5 ± 16.3 | 120.0 ± 18.8 | 117.7 ± 15.4 | 114.8 ± 14.1 |
| Diastolic blood pressure (mmHg) | 75.4 ± 11.0 | 76.2 ± 12.2 | 75.2 ± 10.6 | 75.0 ± 10.3 |
| Fasting blood sugar (mg/dl) | 96.3 ± 14.2 | 95.8 ± 10.5 | 95.1 ± 12.1 | 98.2 ± 18.6 |
| Triglycerides (mg/dl) | 84.5 (62.0, 126.0) | 92.5 (63.8, 130.8) | 86.5 (60.8, 125.3) | 78.5 (62.8, 120.0) |
| HDL cholesterol (mg/dl) | 59.3 ± 13.1 | 58.4 ± 12.2 | 60.1 ± 12.7 | 59.4 ± 14.2 |
| LDL cholesterol (mg/dl) | 117.6 ± 29.7 | 117.5 ± 29.8 | 119.2 ± 27.3 | 116.2 ± 32.0 |
| eGFR (ml/min/1.73 m2) | 74.1 ± 12.6 | 72.5 ± 12.4 | 74.5 ± 14.5 | 75.3 ± 10.8 |
| DNA/RNA oxidation products (μM/g creatinine) | 87.1 (71.3, 117.4) | 78.0 (60.0, 101.5) | 83.0 (71.4, 113.6) | 107.0 (83.9, 133.5)**,†† |
| 15-isoprostane F2t (μM/g creatinine) | 1.47 (0.98, 2.22) | 1.25 (0.68, 1.64) | 1.67 (1.01, 2.40)** | 1.76 (1.22, 3.02)** |
| Urinary pteridines (μM/g creatinine) | 14.3 (11.0, 19.3) | 10.2 (8.8, 11.0) | 14.3 (13.2, 15.2)** | 22.9 (19.2, 27.0)**,†† |
Numbers, percentages, means with standard deviations, and medians with 25 and 75 percentile values are shown.
Symbols denote significant differences from the 1st tertile group (*p < 0.05; **p < 0.01) and the 2nd tertile group (††p < 0.01) for pteridines.