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. 2020 Jul 2;11(7):509. doi: 10.1038/s41419-020-2699-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Expression of miR-4652-3p were downregulated after knockdown of SPEN in HONE1 cells based on a miRNA array. b qRT-PCR detected miR-4652-3p expression in SPEN-silenced HONE1 cells compared with HONE1-NC group. *P < 0.05. c miR-4652-3p expression was remarkably upregulated after miR-4652-3p mimics infection in HONE1 and 5-8 F. ***P < 0.001. miR-4652-3p promoted cell migration and invasion in HONE1 and 5-8F cells examined by transwell, boyden (d) and wound-healing assay (e). *P < 0.05 (f) Representative bioluminescence images of the lungs after tail vein injection of cells. Lung metastases were confirmed by H&E staining. Scale bars, 200 μm. Arrows indicate nests of malignant cells.