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. 2020 Jul 8;11:3410. doi: 10.1038/s41467-020-17240-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Cytolytic molecules were assessed by flow cytometry, and the proportions of CD8+ T lymphocytes co-expression of GNLY, GZMB, PRF were analyzed in HC (n = 6), mild (n = 20), and severe (n = 9) patients of SARS-COV-2 infection. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 by two-tailed Mann–Whitney U-test for b (p = 0.002, p = 0.0004, and p = 0.0386 for GZMB+GNLY+PRF+ cells, p = 0.0006 and p = 0.0004 for GZMB+GNLY-PRF+ cells, p = 0.0459 for GZMB-GNLY+PRF+ cells, p = 0.0331, p = 0.0048, and p = 0.03 for GZMB-GNLY+PRF− cells, p = 0.0026 and p = 0.0496 for GZMB-GNLY-PRF+ cells, and p = 0.0279 and p = 0.012 for GZBM-GNLY-PRF− cells, respectively). Source data included as a Source Data File.